If solved
Drug-free autoimmune remission
A one-time or rare treatment resets the immune system, and people at risk are treated before symptoms begin.
Open in the interactive tree →Drug-free remission would become a normal outcome for lupus, multiple sclerosis, myositis and similar diseases, not a result from small trials. Autoantibody and risk tests would find people years before organ damage, as teplizumab already does for early-stage type 1 diabetes. Treatments would be made inside the body, without cell manufacturing.
What it brings
- Stopping lifelong immune suppression for most patients
- Screening programmes for autoimmune risk
- Treatment of early disease before organs are damaged
- Lower infection and cancer risks from long-term drugs