Researched
L-DOPA for Parkinson's
Carlsson found brain dopamine in 1957 and Hornykiewicz its loss in Parkinson's in 1960; high-dose L-DOPA from 1967 was the first effective treatment.
Open in the interactive tree →The dopamine precursor levodopa restores movement for years; Arvid Carlsson shared the 2000 Nobel Prize for his work on dopamine. Side effects later pushed treatment toward drug combinations and deep brain stimulation.
Prerequisites
Unlocks
- Neuroprostheses and DBS1987DBS is mainly used in Parkinson's disease, where L-DOPA loses its effect over the years
- Dopamine and reward prediction1997
- Alzheimer's and brain declineopenParkinson's, a neurodegenerative disease, got its first effective treatment from L-DOPA